The offering will only be made by means of a prospectus pursuant to a registration statement that is filed with the SEC after such registration statement becomes effective. Additional fu nds will be required to complete the initial Phase 3 trial and additional trials may be required based on guidance from the regulatory agencies after review of the data f rom the initial Phase 3 trial. Free Writing Prospectus Statement. Forward Looking Statements. FDA indicated Adial may proceed with this trial design. Use of Net Proceeds in Millions. Studies suggest that blockade of serotonin - 3 receptors will influence the dopamine reward system activated by alcohol, decreasing dopamine release and attenuating craving for alcohol. AD04 significantly reduced heavy drinking in patients with the targeted genotypes.
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